一系列的研究表明骨骼肌细胞内甘油三酯(intramyocellular triacyglycerol,IMTG)和胰岛素抵抗之间有密切联系。许多因素可调控IMTG的动态变化,如甘油三酯水解酶、激素敏感性脂肪酶、甘油一酯脂肪酶和脂滴结合蛋白等。而IMTG的代谢中间产物甘油二酯、神经酰胺和脂肪酸在骨骼肌中的聚集也与胰岛素抵抗密切相关。脂滴和线粒体对于细胞内甘油三酯及其代谢产物的周转速度起关键作用,对胰岛素抵抗也起着重要的作用。 A series of studies have shown that there is a close relationship between intramyocellular triacyglycerol (IMTG) and insulin resistance in skeletal muscle cells. Many factors regulate the dynamic changes of IMTG, such as triglyceride hydrolase, hormone-sensitive lipase, monoglyceride lipase and lipid-drop binding protein. The metabolic intermediate products of IMTG, such as diglyceride, ceramide and fatty acid in skeletal muscle, are also closely related to insulin resistance. Lipid droplets and mitochondria play key roles in the turnover rate of intracellular triglycerides and their metabolites and also play an important role in insulin resistance.