The compaction of particulate materials to form tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. The general aim of the current study is to understand the relationship between the mechanical properties of single feed particles (< 100 μm) and their compaction behaviour in order to produce tablets at low compression pressure with acceptable strength. The materials studied were pharmaceutical excipients, comprising three enteric polymer particles and three different powders in the form of agglomerates. The mechanical properties of the individual particles or agglomerates were determined by a micromanipulation technique. The samples were also com- pacted in cylindrical tableting dies. It was observed that there was a strong correlation between the forces required to cause the fracture of the single particles and those derived from the compaction measurements as determined using an existing analysis. The compaction of particulate materials to form tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. current study is to understand the relationship between the mechanical properties of single feed particles (<100 μm) and their compaction behavior in order to produce tablets at low compression pressure with acceptable strength. The materials study were pharmaceutical excipients, including three enteric polymer particles and The different characteristics of the individual particles or agglomerates were determined by a micromanipulation technique. The was observed that there was a strong correlation between the forces required to cause the fracture of the single particles and thos e derived from the compaction measurements as determined using an existing analysis.