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选取70例口服药控制不佳的老年T2DM患者,在原口服降糖药不变的基础上随机加用地特胰岛素或甘精胰岛素,每组35例,治疗期为12周。结果两组的HbA1c、FBG和2h-BG均有明显下降(P<0.05),但组间比无统计学意义(P>0.05);与对照组相比,治疗组体重增加少,差异有统计学意义(P<0.05);治疗组发生低血糖事件的发生率(11.43%)低于对照组(14.28%),但(P>0.05))。结论口服药治疗不佳的2型糖尿病患者,加用1天1次地特胰岛素治疗同甘精胰岛素相比,有效性、安全性相似,但低血糖事件发生率低、体重增加少。
70 elderly patients with poorly controlled T2DM were enrolled in this study. Dextr insulin or insulin glargine were randomly added to the unchanged oral hypoglycemic agents in 35 patients in each group for 12 weeks. Results The levels of HbA1c, FBG and 2h-BG in both groups were significantly decreased (P <0.05), but there was no significant difference between two groups (P> 0.05). Compared with the control group, the weight gain of the treatment group was less (P <0.05). The incidence of hypoglycemia in treatment group (11.43%) was lower than that in control group (14.28%) (P> 0.05). Conclusion In patients with type 2 diabetes treated with oral medication, insulin treatment with insulin glargine once a day is similar in efficacy and safety to those with type 2 diabetes. However, the incidence of hypoglycaemia is low and body weight gain is low.