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1例53岁女性患者行右卵巢子宫内膜样腺癌根治术后接受6周期的紫杉醇联合卡铂化疗。每个周期为21d。每周期第1d分别静脉滴注紫杉醇270mg和卡铂700mg,之后休息20d。第3周期化疗结束后,患者出现双足麻木。在第4～6化疗周期,患者双足麻木症状加重,双下肢无力,导致站立和行走困难。给予复合维生素B片及甲钴胺注射液,症状未缓解。考虑该不良反应与紫杉醇和卡铂联用有关。给予胸腺五肽1mg,1次/d静脉滴注,复方苦参注射液15ml,1次/d静脉滴注,口服维生素B660mg,2次/d及中药汤剂。15d后,患者症状减轻。
A 53-year-old woman undergoing right-ovariectomy-like adenocarcinoma received 6 cycles of paclitaxel plus carboplatin chemotherapy. Each cycle is 21d. Paclitaxel 270mg and carboplatin 700mg were intravenously administered on the first day of each cycle, and then rest for 20 days. After the end of the third cycle of chemotherapy, patients with feet numbness. In the 4th to 6th cycles of chemotherapy, the patient experienced worsening numbness symptoms and weakness in both lower extremities, resulting in difficulty standing and walking. Given vitamin B tablets and mecobalamin injection, the symptoms did not ease. Consider the side effects associated with paclitaxel and carboplatin. Given thymopentin 1mg, 1 / d intravenous infusion of compound Kushen injection 15ml, 1 / d intravenous infusion of vitamin B660mg, 2 times / d and decoction. After 15 days, the patient’s symptoms were relieved.