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探讨感觉神经肽对大鼠急性缺氧性肺、脑血管反应的影响。方法用辣椒素毁损肽能感觉神经，观察对缺氧性肺血管收缩反应（ＨＰＶ）和缺氧性脑血管舒张反应（ＨＣＶＤ）的影响；用放射免疫测定法和免疫组化法分别观察急性缺氧时肺循环中Ｐ物质（ＳＰ）及肺组织中肽能神经纤维的变化；观察外源性ＳＰ对ＨＰＶ和ＨＣＶＤ的影响。结果发现辣椒素处理的新生大鼠成年后平均肺动脉压（２．４６±０．０７ｋＰａ，１ｋＰａ＝７．５ｍｍＨｇ）、肺血管阻力（３６６５±１６４ｋＰａ．ｓ／Ｌ）和缺氧性肺血管阻力变化率（９８．７％±４．１％）高于溶剂对照（ｔ分别为２．８９、３．４９和１２．１８，Ｐ均〈０。０１）和正常对照组（ｔ分别为３．０９、３．５９和１３．４８，Ｐ均＜０．０１），差异均有非常显著意义；其基础脑阻抗血流图波幅（１１．３±１．０ｍΩ）则低于二对照组（ｔ分别为２．４９和２．６９，Ｐ均＜０．０５），差异有显著意义；急性缺氧时二对照组脑阻抗血流图波幅分别增高４１．４％±６．７％和４８．８％±６．１％，而辣椒素处理组反而降低２３．６％±２．４％，（ｔ分别为９．４４和１１．２１，Ｐ均＜０．０１）差异有非常显著意义。急性缺氧鼠出肺血中ＳＰ较入肺血增多（１３９±?
To investigate the effect of sensory neuropeptide on acute hypoxic pulmonary and cerebrovascular responses in rats. Methods Capsaicin was used to destroy the sensory nerves of the peptide and observe the effects on hypoxic pulmonary vasoconstriction (HPV) and hypoxic cerebrovascular vasodilation (HCVD). Radioimmunoassay and immunohistochemistry were used to observe acute hypoxia Changes of P substance (SP) in pulmonary circulation and peptide nerve fibers in lung tissue during oxygenation; and the effects of exogenous SP on HPV and HCVD were observed. The results showed that the mean pulmonary arterial pressure (2.46 ± 0.07kPa, 1kPa = 7.5mmHg), pulmonary vascular resistance (3665 ± 164kPa.s / L) and hypoxic pulmonary vascular resistance The rates (98.7% ± 4.1%) were higher than those of the solvent control (t = 2.89, 3.49 and 12.18, respectively, P <0.01) , 3.59 and 13.48 respectively, P <0.01), the differences were significant (P <0.01). The amplitude of basal cerebral blood flow (11.3 ± 1.0mΩ) was lower than that of the control group 2.49 and 2.69 respectively, P <0.05), and the difference was significant. The amplitude of cerebral impedance blood flow in two control groups increased 41.4% ± 6.7% and 48.8 % ± 6.1%, while the capsaicin treatment group decreased 23.6% ± 2.4% (t = 9.44 and 11.21 respectively, P <0.01), but the difference was significant Meaning. Acute hypoxia rat pulmonary SP increased into the lung blood increased (139 ±?