粒细胞—巨噬细胞集落刺激因子(GM—CSF)是一重要的造血生长因子,由活化的T细胞、成纤维细胞、单核巨噬细胞、上皮细胞、内皮细胞等产生,是一种含144个氨基酸的糖蛋白。在粒、巨、单核细胞的生成调节中起重要作用。它可刺激多潜能造血母细胞的分化,产生粒、单、巨噬、嗜酸、红系、巨核细胞母细胞;调节上述成熟细胞的功能。 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor, which is produced by activated T cells, fibroblasts, monocyte-macrophages, epithelial cells, endothelial cells, 144 amino acid glycoprotein. It plays an important role in the regulation of granulosa, macrophage and monocyte. It stimulates the differentiation of multipotent hematopoietic progenitor cells, producing granulocytes, monocytes, macrophages, eosinophils, erythroid cells and megakaryocyte blasts; and regulates the function of the above mature cells.