微小RNA(miRNAs)是一族内源性非编码单链小RNA,通过结合靶基因mRNA的3’端非翻译区在转录后水平负性调节基因的表达。研究发现某些miRNAs的异常表达与前列腺癌(PCa)等多种肿瘤的发生密切相关,通过分析PCa组织、PCa患者血清和PCa细胞株中多种miRNAs的异常表达,并探讨其具体机制,可为临床PCa的诊断及治疗提供新的理论依据。 MicroRNAs (miRNAs) are a family of endogenous, non-coding single-stranded small RNAs that negatively regulate gene expression at the post-transcriptional level by binding to the 3 ’untranslated region of the target gene mRNA. It is found that the abnormal expression of some miRNAs is closely related to the occurrence of many cancers such as prostate cancer (PCa). By analyzing the abnormal expression of multiple miRNAs in PCa tissues, PCa patients and PCa cell lines, and to explore its specific mechanism, Provide a new theoretical basis for the diagnosis and treatment of clinical PCa.