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紫杉醇通过干预癌细胞微管蛋白的聚合与解聚以及阻碍有丝分裂等方式中断细胞的生长,促进癌细胞凋亡,在乳腺癌治疗中有较好疗效。然而,由于其难溶于水,临床实践中用聚氧乙烯蓖麻油与无水乙醇的混合剂作为溶媒。聚氧乙烯蓖麻油是一种表面活性剂,容易引起严重的过敏反应,即使常规在用药前使用皮质激素和抗组胺类药物作为预处理,仍有超过2%的严重过敏反应;并且聚氧乙烯蓖麻油的使
Paclitaxel interferes with the growth of cancer cells by inhibiting the polymerization and disaggregation of tubulin and blocking the mitosis. It promotes the apoptosis of cancer cells and has a good effect in the treatment of breast cancer. However, because of its poor solubility in water, a combination of polyoxyethylene castor oil and absolute ethanol is used as a vehicle in clinical practice. Polyoxyethylene castor oil is a surfactant that can easily cause severe allergic reactions and even with conventional administration of corticosteroids and antihistamines as pretreatment, more than 2% of severe allergic reactions remain; and polyoxygen The use of ethylene castor oil