论文部分内容阅读
目的:认识和分析BMP及其受体与口腔鳞癌发生、发展的可能关系。方法:用免疫组织化学方法分析BMP-5、BMP受体BMPR-IA在口腔颊部粘膜正常上皮、慢性炎症和癌变中的表达,标本为:18例正常上皮(normal buccal mucosa,NB),24例慢性炎症(nonspecofic chronic inflammation.NCl),58例鳞癌(squamous cell carcinoma,SCC)。结果:BMP-5、BMPR-IA在口腔粘膜的正常与慢性炎症上皮中有弱表达,NB与NCI无明显差别;在鳞癌上皮中除2例BMP-5表达为阴性外,余均有阳性或强阳性表达,明显高于NB、NCI两组;鳞癌中高分化、中分化、低分化三组间的表达无明显差别。结论:BMP-5、BMPR-IA可能参与了对口腔鳞癌发生、发展的调控。
Objective: To understand and analyze the possible relationship between BMP and its receptor and the occurrence and development of oral squamous cell carcinoma. Methods: The expressions of BMP-5 and BMP receptor BMPR-IA in normal, chronic inflammation and carcinogenesis of oral buccal mucosa were analyzed by immunohistochemistry. The specimens were 18 cases of normal buccal mucosa (NB), 24 Cases of chronic inflammation (nonspecofic chronic inflammation. NCl), 58 cases of squamous cell carcinoma (SCC). Results: BMP-5 and BMPR-IA were weakly expressed in the normal and chronic inflammatory epithelia of oral mucosa. There was no significant difference between NB and NCI. In addition, BMP-5 and BMPR- Or strongly positive expression was significantly higher than the NB, NCI two groups; moderately differentiated, moderately differentiated, poorly differentiated squamous cell carcinoma among the three groups expression no significant difference. Conclusion: BMP-5 and BMPR-IA may be involved in the regulation of the occurrence and development of oral squamous cell carcinoma.