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目的探讨螺内酯联合小剂量倍他乐克治疗充血性心力衰竭的临床疗效。方法回顾性分析徐州医学院附属三医院近年来收治的120例充血性心力衰竭患者的临床资料,将患者随机分为2组,治疗组和对照组,比较2组患者的临床疗效差异。结果对照组60例充血性心力衰竭患者,总有效率为71.67%,治疗组60例患者,总有效率为91.67%;两组患者的临床疗效经统计学分析,P<0.05,具有显著性差异。对照组患者治疗前的心率、心输出量及射血分数与治疗组患者治疗前测量指标比较无明显差异性,治疗组患者治疗后的各项指标与对照组治疗后比较,差异有显著性,P<0.01。结论螺内酯联合小剂量倍他乐克治疗充血性心力衰竭的临床疗效确切,对患者的心率、心输出量及射血分数等有明显的改善作用,值得临床推广使用。
Objective To investigate the clinical effect of spironolactone combined with low-dose Betaloc on congestive heart failure. Methods The clinical data of 120 patients with congestive heart failure admitted to the Third Affiliated Hospital of Xuzhou Medical College were retrospectively analyzed. The patients were randomly divided into two groups, the treatment group and the control group. The differences in clinical efficacy between the two groups were compared. Results The control group 60 patients with congestive heart failure, the total effective rate was 71.67%, 60 patients in the treatment group, the total effective rate was 91.67%; two groups of patients with clinical efficacy by statistical analysis, P <0.05, with significant differences . The control group patients before treatment, heart rate, cardiac output and ejection fraction compared with the treatment group before treatment did not show any significant difference in the indicators of the treatment group after treatment compared with the control group after treatment, the difference was significant, P <0.01. Conclusion Spironolactone combined with low-dose Betaloc therapy in the treatment of congestive heart failure has definite curative effect on heart rate, cardiac output and ejection fraction, which is worthy of clinical promotion.