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目的观察持续性心房颤动(PAf)患者C反应蛋白(CRP)水平的变化,并探讨CRP与PAf患者复律后复发的关系。方法比较无器质性心脏病PAf患者与正常人群的CRP水平。对PAf患者行药物及电复律治疗,复律成功后随访1个月,比较复律后复发者及维持窦性心律者CRP水平。结果PAf组CRP水平显著高于对照组(P<0.05);复律后,复发亚组CRP水平显著高于维持亚组;回顾分析,复律前复发亚组的CRP水平亦显著高于维持亚组。结论CRP水平与PAf的发生有显著关系,对PAf患者复律治疗的预后有一定的预测作用。
Objective To observe the changes of C-reactive protein (CRP) level in patients with persistent atrial fibrillation (PAf) and to explore the relationship between CRP and recurrence after cardioversion in patients with PAf. Methods The CRP levels in patients with PAf without organic heart disease and in normal people were compared. PAf patients underwent drug and electrical cardioversion therapy, follow-up 1 month after successful cardioversion, relapse after cardioversion and maintenance of sinus rhythm CRP levels. Results The level of CRP in PAf group was significantly higher than that in control group (P <0.05). After cardioversion, the level of CRP in recurrence subgroup was significantly higher than that in maintenance subgroup. According to the retrospective analysis, the CRP level in subgroup before recurrence was significantly higher than that in maintenance subgroup group. Conclusion There is a significant relationship between the level of CRP and the occurrence of PAf, and the prognosis of patients with PAf may have some predictive value.