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髓样细胞触发受体(triggering receptors expressed on mye-loid cells,TREM)是免疫球蛋白超家族的一个受体家族,包括3个激活型受体(TREM-1,TREM-2,TREM-3)和1个抑制型受体(TREM like transcript-1,TLT-1)。TREM-1主要表达于血液中性粒细胞、单核细胞表面,选择性地表达于肺泡液、肠液及其他体液的巨噬细胞表面,能够增强Toll样受体介导的炎症反应。在炎症反应中发挥主导作用。其通过特殊的细胞信号转导途径促进促炎介质的产生、抑制抗炎介质的表达而激活和放大
Triggering receptors expressed on mye-loid cells (TREMs) are a family of receptors for the immunoglobulin superfamily and include three activated receptors (TREM-1, TREM-2, TREM-3) And one TRT-like transcript-1 (TLT-1). TREM-1 is mainly expressed on the surface of blood neutrophils and monocytes and selectively expressed on the surface of macrophages of alveolar fluid, intestinal fluid and other body fluids, which can enhance the Toll-like receptor-mediated inflammatory reaction. In the inflammatory response to play a leading role. It promotes the production of proinflammatory mediators through specific cellular signal transduction pathways, inhibits the expression of anti-inflammatory mediators and activates and amplifies