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胆红素脑病是由于未结合胆红素在脑细胞的沉积所引起的一种中毒性脑痛。本病严重威胁新生儿生命和健康,死亡率极高,约1/2～3/4的患儿于急性期死亡;幸存者约90％留有严重的神经系统后遗症。因此,预防胆红素脑病的发生是非常重要的。而研究胆红素脑病的发病机制及其影响因素对脑病的防治具有极其重要的意义。自从1904年Schmorl首先提出这一疾病以来,关于胆红素脑病的发生机制已进行了多少方面的研究,但到目前为止,尚无一种全面的、公认的解释。一、游离胆红素学说
Bilirubin encephalopathy is a toxic brain ache caused by unconjugated bilirubin deposition in brain cells. The disease poses a serious threat to the life and health of newborns. The mortality rate is extremely high. About one-third to three-quarters of children die in the acute phase; about 90% of the survivors have serious neurological sequelae. Therefore, the prevention of the occurrence of bilirubin encephalopathy is very important. The study of the pathogenesis of bilirubin encephalopathy and its influencing factors on the prevention and treatment of encephalopathy is extremely important. Since Schmorl first proposed the disease in 1904, much has been done on the mechanism of bilirubin encephalopathy, but so far there is no comprehensive and accepted explanation. First, free bilirubin theory