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黑暗链霉菌可产生一种属于氨基环醇类抗生素的尼拉霉素(nebramycin)复合物。该复合物是由3种主要组分;阿普拉霉素。6″-O-氨甲酰基卡那霉素B与6″-0-氨甲酰基妥布拉霉素,以及一些次要组分所组成。阿普拉霉素可用作兽药,而6″-O-氨甲酰基卡那霉素B与6″-O-氨甲酰基妥布拉霉素经碱性水解,分别生成适于临床应用的卡那霉素B和妥布拉霉素。由于妥布拉霉素在治疗葡萄球菌及假单胞菌感染方面已证明是一种有效药物,故其工业生产具有重要意义。用于抗生素微生物测定的检定菌对所试验的所有组分均敏感,故琼脂扩散试验中的抑菌圈直
Streptomyces dark can produce a nebramycin complex that is an aminocyclitol antibiotic. The complex is composed of 3 main components; apramycin. 6 “-O-carbamyl kanamycin B and 6” -O-carbamoyl tobramycin, as well as some minor components. Apramycin is useful as a veterinary drug, while 6 “-O-carbamyl kanamycin B and 6” -O-carbamoyl tobramycin are alkaline hydrolyzed to produce, respectively, suitable for clinical use Kanamycin B and Tobramycin. As tobramycin has proven to be an effective drug in the treatment of staphylococci and Pseudomonas infections, its industrial production is of great importance. The test bacteria used for the antibiotic microbiological assay were all sensitive to all the components tested, so the zone of inhibition in the agar diffusion test was straight