非甾体抗炎(NSAI)剂主要用于控制关节炎和有关结缔组织疾病的症状。近年来已日益重视免疫调节剂用于类风湿性关节炎(RA)这种免疫介入关节炎形式的作用研究。通过炎症动物模型的研究近年不断发现上述两类药的一些新药。本文综述1977年以来这两类药中较有效的新药中有关药理学和临床方面的文献。特别着重于动物和人口服有效的药物,因为其他给药途径在高剂量时,由于毒性或局部刺激作用可产生假阳性。 Non-steroidal anti-inflammatory (NSAI) agents are mainly used to control the symptoms of arthritis and related connective tissue diseases. In recent years, the role of immunomodulators in the form of immune-mediated arthritis of rheumatoid arthritis (RA) has been increasingly emphasized. In recent years, the discovery of some new drugs of the above two types of drugs has been continuously made through the study of animal models of inflammation. This article reviews the literature on pharmacology and clinical aspects of the more effective new drugs in both groups since 1977. Special emphasis is placed on animals and people orally effective drugs, because other routes of administration at high doses, due to toxicity or local irritation can produce false positives.