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目的观察异常子宫出血患者子宫内各部位内膜组织雌激素受体(estrogen receptor,ER)、孕激素受体(progestron receptor,PR)表达有无差异,为宫腔镜下子宫内膜电切术切除范围提供理论依据。方法门诊宫腔镜下观察异常子宫出血须诊刮及部分行子宫全切除术的患者宫腔内不同部位的子宫内膜组织,用免疫组织化学方法测定ER、PR含量,采用LeicaQ500IW图像分析仪进行测定,应用光密度值进行比较。结果异常子宫出血患者子宫腔内各部位内膜增生情况不同:ER、PR含量从高到低的顺序为:宫底>子宫体部>子宫角部>宫颈峡部;ER、PR在子宫腔内各部位分布情况的不同具有相关性。结论对于宫底部高ER、PR状态,要引起高度重视;经宫颈子宫内膜电切术(transcervical resection of endometrium,TCRE)或子宫内膜热球剥脱术(uterine balloon thermablate,UBT)。术中谨慎并彻底处理宫底与双侧宫角部的子宫内膜组织,破坏其内膜的结构,避免复发和恶化。
Objective To observe the difference of estrogen receptor (ER) and progestron receptor (PR) expression in endometrial tissue of patients with abnormal uterine bleeding, and to evaluate the effect of hysteroscopic endometrial resection Removal of the scope to provide a theoretical basis. Methods Outpatient hysteroscopic abnormal uterine bleeding to be diagnosed and some patients underwent hysterectomy in different parts of the uterine cavity of the endometrial tissue, immunohistochemical determination of ER, PR content using LeicaQ500IW image analyzer Determination, the application of optical density values for comparison. Results Intimal hyperplasia in different parts of uterine cavity of patients with abnormal uterine bleeding were different: the order of ER and PR was from high to low: uterus> uterine horn> uterine horn> cervical isthmus; ER and PR in uterine cavity The distribution of different parts of a correlation. CONCLUSIONS: High ER and PR status in the bottom of the uterus should be paid great attention to. Transcervical resection of endometrium (TCRE) or uterine balloon thermablate (UBT) are the most important. Intraoperative cautious and thorough treatment of the uterus and bilateral uterine endometrial tissue, destruction of the structure of its intima, to avoid recurrence and deterioration.