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目的探讨尼莫地平治疗老年高血压性脑出血患者的临床效果。方法 90例老年高血压性脑出血患者,随机分成研究组及对照组,各45例。两组均采用止血、降颅压、保持水电解质平衡等常规治疗,对照组在常规治疗的基础上加用硝普钠进行治疗,研究组在常规治疗的基础上加用尼莫地平进行治疗。比较分析两组治疗前后神经功能缺损评分(NIHSS)及临床疗效。结果研究组总有效率91.1%高于对照组73.3%,差异具有统计学意义(χ~2=4.865,P<0.05)。治疗前,两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗3周末,两组患者NIHSS评分均较治疗前下降,且研究组患者治疗后NIHSS评分明显低于对照组,差异均具有统计学意义(P<0.05)。结论尼莫地平治疗老年高血压性脑出血患者的临床效果优于硝普钠的治疗效果,可有效改善患者脑神经功能缺损程度,值得应用。
Objective To investigate the clinical effect of nimodipine in the treatment of senile hypertensive intracerebral hemorrhage. Methods Ninety elderly patients with hypertensive intracerebral hemorrhage were randomly divided into study group and control group, with 45 cases in each group. The two groups were treated with conventional therapy such as hemostasis, intracranial pressure reduction and water / electrolyte balance. The control group was treated with sodium nitroprusside on the basis of conventional treatment. The study group was treated with nimodipine on the basis of conventional treatment. Comparative analysis of the two groups before and after treatment neurological deficit score (NIHSS) and clinical efficacy. Results The total effective rate was 91.1% in the study group and 73.3% in the control group. The difference was statistically significant (χ ~ 2 = 4.865, P <0.05). Before treatment, there was no significant difference in NIHSS scores between the two groups (P> 0.05). After 3 weeks of treatment, the NIHSS scores of both groups decreased compared with before treatment, and NIHSS scores of the study group were significantly lower than those of the control group, The differences were statistically significant (P <0.05). Conclusion Nimodipine is superior to sodium nitroprusside in treating senile hypertensive intracerebral hemorrhage. It is effective in improving neurological deficit in patients with cerebral hemorrhage. It is worth to be applied.