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[目的]分析非受体型蛋白酪氨酸磷酸酶22(PTPN22)基因多态性与儿童血小板减少性紫癜(ITP)易感性的关联性.[方法]通过复合PCR和基质辅助激光解电离析飞行时间质谱(PCR-MALDI-TOF-MS)法对120例ITP患儿(观察组)及80例正常儿童(对照组)PTPN22基因-1123G>C(rs2488457)测定.[结果]观察组PTPN22-1123G>C等位基因中C频率62.50%,较对照组的71.25%差异有统计学意义(P0.05);观察组与对照组男童等位基因频率比较差异显著(P0.05),两组同一性别基因型比较差异均无统计学意义(P>0.05).[结论]PTPN22-1123G>C多态性与儿童ITP易感性有关,C为优势等位基因,G为风险等位基因,PTPN22-1123G>C等位基因频率分布可能与儿童性别相关.“,”[Objective]To analyze the correlation between non-receptor protein tyrosine phosphatase 22 (PTPN22) gene polymorphism and the susceptibility of idiopathic thrombocytopenic purpura (ITP) in children.[Methods]Gene polymorphism of PTPN22-1123G>C (rs2488457) in 120 children with ITP (the observation group) and 80 normal children (the control group) was determined by PCR-MALDI-TOF MS method.[Results]The C frequency of PTPN22-1123G > C allele in the observation group was 62.50% ,which was significantly lower than that in the control group (71.25%) (P0.05).The allele frequency showed significant differences in boys in the two groups (P0.05).There were no significant differences in genotypes in children with the same gender (P>0.05).[Conclusion]The PTPN22-1123G>C polymorphism is associated with susceptibility of ITP in children.C is the dominant allele while G is the risk allele.The allele frequencies of PTPN22-1123G > C may be related to the gender of children.