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目的观察脑出血患者发病后2周内血清肿瘤坏死因子-α(TNF-α)含量的变化及其与C-反应蛋白(CRP)的相关性。方法用放射免疫法测定高血压脑出血患者发病后24h、7d、14d血清TNF-α,用免疫比浊法测定CRP含量,并进行相关性分析。结果患者血清TNF-α及CRP均在发病后24h升高,TNF-α7d时达高峰,14d时又下降,但仍高于对照组;急性期TNF-α含量和CRP与出血量及血肿周围水肿区体积呈正相关。结论CRP、TNF-α参与了脑出血的病理生理过程,出血量及血肿周围水肿区体积越大,TNF-α和CRP的含量越高,两者可作为神经元损伤定量生化指标的标记物,也可作为监测病情变化和药物疗效评价的指标。
Objective To observe the changes of serum tumor necrosis factor-α (TNF-α) and its correlation with C-reactive protein (CRP) within 2 weeks after the onset of cerebral hemorrhage. Methods Serum levels of TNF-α were determined by radioimmunoassay at 24h, 7d and 14d after onset of cerebral hemorrhage in hypertensive patients. CRP levels were determined by immunoturbidimetry and the correlation was analyzed. Results Serum levels of TNF-α and CRP increased at 24 h after onset and peaked at 7 d of TNF-α, then decreased at 14 d, but still higher than those of the control group. The levels of TNF-α, CRP and hemorrhage and hematoma around the hematoma Zone volume was positively correlated. Conclusion CRP and TNF-α are involved in the pathophysiological process of cerebral hemorrhage. The larger the volume of hemorrhage and the area around the hematoma, the higher the levels of TNF-α and CRP, both of them can be used as markers of quantitative and biochemical indexes of neuronal injury. Can also be used as indicators to monitor changes in condition and drug efficacy.