论文部分内容阅读
缓脉灵是1932年由夹竹桃科植物印度萝芙木中提出的一种生物碱,1956年Arora氏和Madan二氏首先发表缓脉灵有强效的抗心律失常作用,除对房性和室性心律失常有治疗作用外,治疗吾—巴—怀(Wolff-Parkinson-White)氏综合征特别有效。 一、对心率的作用:在清醒的狗身上用0.25毫克/公斤的剂量时对心率无显著影响。只有用4.0毫克/公斤的大剂量时对心率才有明显加快作用。 二、对血压的作用:在清醒狗的实验研究中4.0毫克/公斤的剂量时才显著提高动脉血压,而8.0毫
In 1956, Brahma Ling was an alkaloid proposed by Apocynaceae Indian Rauvolfia in 1932. In 1956, Arora’s and Madan’s II first published that there was a potent anti-arrhythmic effect. In addition to the therapeutic effects of ventricular arrhythmias, Wolff-Parkinson-White syndrome is particularly effective. First, the role of heart rate: the awake dog with 0.25 mg / kg dose did not significantly affect the heart rate. Only with 4.0 mg / kg of large doses when the heart rate was significantly accelerated. Effects on Blood Pressure: Arterial blood pressure was significantly increased at a dose of 4.0 mg / kg in awake dog experimental studies, whereas 8.0 milliamperes