草甘膦作为广谱灭生性有机膦除草剂,具有极为优良的生物特性,被广泛应用在农业生产中。近年来,随着转基因抗草甘膦作物如大豆、玉米、棉花等的研制开发和大规模种植,全球对草甘膦的需求量持续增加。草甘膦的化学合成包括氯甲基磷酸法、甘氨酸法、亚氨基二乙酸法及双甘膦法等多种方法。1.氯甲基磷酸法(压力法)以三氯化磷(PCl3)、多聚甲醛以及甘氨酸作为主要原料。该工艺路线短,所用原 Glyphosate, as a broad-spectrum, biocidal organophosphine herbicide, has very good biological properties and is widely used in agricultural production. In recent years, with the development and large-scale cultivation of transgenic glyphosate-resistant crops such as soybean, corn, cotton and the like, the global demand for glyphosate continues to increase. Chemical synthesis of glyphosate, including chloromethyl phosphoric acid method, glycine method, iminodiacetic acid method and a variety of methods such as PMIDA. 1. Chloromethyl phosphate method (pressure method) to phosphorus trichloride (PCl3), paraformaldehyde and glycine as the main raw material. The process route is short, the original used