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目的:探究奥美拉唑治疗消化性溃疡合并上消化道出血的疗效。方法:从2013年3月到2015年4月于我院治疗的消化性溃疡合并上消化道出血病例中,选取102例作为研究对象,随机采用奥美拉唑治疗的观察组(52例)与采用雷尼替丁治疗的对照组(50例),两组均治疗5d,观察两组患者的生命体征变化。结果:采用奥美拉唑治疗的观察组共39例显效,占75.0%,10例有效,占19.2%,3例无效,占5.8%。总有效49例,占94.2%。采用雷尼替丁治疗的对照组,显效31例,占62.0%,有效8例,占16.0%,无效11例,占22.0%,总有效39例,占78.0%.两组疗效有统计差异(p<0.05),此外经过5d的治疗后两组的生命体征均有改善,其中观察组的改善情况较对照组更为明显(p<0.05)。两组在治疗过程中均未出现药物引发的不良反应病例。结论:采用奥美拉唑治疗消化性溃疡合并上消化道出血的疗效确切,治疗消化性溃疡合并消化道出血安全、有效,值得推广。
Objective: To investigate the curative effect of omeprazole on peptic ulcer with upper gastrointestinal hemorrhage. Methods: From March 2013 to April 2015 in our hospital treated peptic ulcer patients with upper gastrointestinal bleeding, 102 cases were selected as the research object, randomly treated with omeprazole in the observation group (52 cases) and In the control group (n = 50) treated with ranitidine, both groups were treated for 5 days, and the changes of vital signs in the two groups were observed. Results: In the observation group treated with omeprazole, 39 cases were markedly effective, accounting for 75.0%, 10 cases were effective, accounting for 19.2%, 3 cases were ineffective, accounting for 5.8%. The total effective 49 cases, accounting for 94.2%. In the control group treated with ranitidine, there were 31 cases markedly effective, 62.0% effective, 8 effective, 16.0% effective, 11 ineffective, accounting for 22.0%, 39 effective, accounting for 78.0% p <0.05). In addition, the vital signs of both groups were improved after 5 days of treatment. The improvement of the observation group was more obvious than that of the control group (p <0.05). No adverse drug reactions occurred in both groups in the course of treatment. Conclusion: Omeprazole treatment of peptic ulcer complicated with upper gastrointestinal bleeding, the exact effect of treatment of peptic ulcer complicated with gastrointestinal bleeding is safe and effective, it is worth promoting.