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早在40年代,女性激素就开始用于治疗先兆流产、习惯性流产、早产、不育及痛经等,同时还用作堕胎药和妊娠试验药物。近20年来更广泛地用作避孕药物。由于激素避孕药的使用和计划生育工作的开展,女性激素成了医药史上使用最广泛的一类药物。据估计全世界目前有6,500万妇女服用口服避孕药,有200万妇女正在使用长效激素避孕针剂。在临床上使用的天然及合成的性激素衍生物已超过30余种,除用作避孕、治疗痛经和不育外,在其它方面的应用往往是缺少有力的科学根据。由于这些药物,无论是在怀孕前不久、刚怀孕后或怀孕中使用已有多年,从而对于这类药物是否影响胎儿的发育和婴儿的健康已引起人们的关注。
As early as the 1940s, female hormones began to be used in the treatment of threatened abortion, habitual abortion, premature birth, infertility and dysmenorrhea, etc., but also for abortion drugs and pregnancy test drugs. More widely used as contraceptives in nearly 20 years. Because of the use of hormonal contraceptives and family planning work, female hormones have become the most widely used class of medicine in the history of medicine. It is estimated that 65 million women in the world currently consume oral contraceptives and 2 million are using long-acting hormonal injectables. In clinical use of natural and synthetic derivatives of sex hormones have more than 30 species, in addition to contraception, the treatment of dysmenorrhea and infertility, in other applications are often lack of strong scientific basis. As these drugs have been used for many years immediately before or immediately after pregnancy or during pregnancy, attention has been drawn to whether such drugs affect the development of the fetus and the health of infants.