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将镰形棘豆全草分为地上和地下部分,分别用不同溶剂提取得到地上水溶、地下水溶、地上脂溶、地下脂溶4种提取物。各提取物以最大剂量(以生药量计为50 g·kg-1·d-1)连续灌胃小鼠15 d,各组小鼠外观和行为未见明显异常,但脏器系数、血液生化指标、组织病理切片等分析表明地上和地下脂溶性提取物对小鼠肝脏有轻中度损伤,地上和地下水溶性提取物及地下脂溶性提取物对小鼠肾脏有轻度损伤。化学成分分析表明地上和地下脂溶性提取物含有丰富的黄酮苷元,尤以地上部分含量较高,而多糖和蛋白含量较低;地上和地下水溶性提取物则含有较多多糖和蛋白,黄酮苷元含量较低。
The whole grass of Oxytropis falcate was divided into above-ground and underground parts, and four kinds of extracts of aboveground water-soluble, underground water-soluble, aboveground fat-soluble and underground fat-soluble were respectively extracted with different solvents. The mice were given gavage for 15 days at the maximum dose (50 g · kg-1 · d-1), the appearance and behavior of the mice in each group showed no obvious abnormalities, but the organ coefficient, blood biochemistry Indicators, histopathological sections and other analysis showed that above and below fat-soluble extract of mice had mild to moderate liver damage, aboveground and underground water-soluble extract and fat-soluble extract of the ground mice had mild damage to the kidneys. Chemical composition analysis showed that aboveground and underground fat-soluble extracts were rich in flavonoid aglycone, especially in the upper part of the content is higher, while the polysaccharide and protein content is lower; aboveground and underground water-soluble extract contains more polysaccharides and proteins, flavonoid glycosides Low elemental content.