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目的 研究非小细胞肺癌 (NSCLC)患者血清可溶性细胞间粘附分子 - 1(sICAM - 1)水平的临床意义。方法 收集 5 1例不同TNM分期的NSCLC患者血清 ,双夹心ELISA法检测sICAM - 1水平。结果 NSCLC组血清sICAM - 1水平显著高于健康对照组 ,并与肺癌的临床分期有关。结论 sICAM - 1对肺癌的发展、转移有重要意义 ,可作为肺癌的一项预后指标
Objective To investigate the clinical significance of serum soluble intercellular adhesion molecule - 1 (sICAM - 1) in patients with non small cell lung cancer (NSCLC). Methods Fifty - one NSCLC patients with different TNM stages were collected for serum level of sICAM - 1 by double - sandwich ELISA. Results The level of serum sICAM - 1 in NSCLC group was significantly higher than that in healthy control group, which was related to the clinical stage of lung cancer. Conclusion sICAM - 1 is of great significance for the development and metastasis of lung cancer and may be used as a prognostic indicator of lung cancer