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目的:探讨有机硼酸类作为催化剂应用于有机合成反应中作用及对生成物结构的影响。方法:以葡萄胺酸盐作为反映原材料,以硼酸类作为化学合成催化剂,探讨在碱性条件下生成2,5﹣脱氧果糖嗪的工艺控制条件、反应过程、反应条件,并采用质谱、元素分析、核磁共振对合成物熔点及溶解度进行测定。结果:经合成反应发现,硼酸作为催化剂对2,5﹣脱氧果糖嗪合成工艺产生较理想的影响,合成的2,5﹣脱氧果糖嗪不溶于丙二醇溶液中,但在异丙醇、甲醇、丙醇溶液等有机溶剂中具有一定的溶解度,但一般情况下不超过3mg/mL,其其溶解度随着含水量的增加而增大。合成产物作为目标物其产率为58.6%,纯度≥97%.结论:有机硼剂作为2,5﹣脱氧果糖嗪反应催化剂较适宜,具有反应条件吻合、原料种类较少、操作监控简单、低污染、流程短、能耗低等优点。
OBJECTIVE: To investigate the effects of organic boronic acids as catalysts on organic synthesis reactions and their effects on the structure of products. Methods: Using gluconate as the raw material and boric acid as the catalyst for chemical synthesis, the process conditions, reaction conditions and reaction conditions for producing 2,5-deoxy fructosine under alkaline conditions were discussed. , NMR measurement of the melting point and solubility of the composition. Results: It was found by synthesis reaction that boric acid was the ideal catalyst for the synthesis of 2,5-deoxy-fructosine. The synthesized 2,5-deoxy-fructosine did not dissolve in propylene glycol solution, but in isopropanol, methanol, Alcohol solution and other organic solvents have a certain degree of solubility, but under normal circumstances does not exceed 3mg / mL, its solubility increases with the increase of water content. The yield of the synthesized product was 58.6% and the purity was ≥97% .Conclusion: The organoboron as the catalyst for 2,5-deoxy fructosine reaction is more suitable, which has the same reaction conditions, less raw materials, simple operation control, low Pollution, short process, low energy consumption and other advantages.