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目的 :研究后程加速超分割放疗对食管癌的疗效。方法 :自 1996年 4月～ 1999年 4月对收治的 15 2例首程治疗食管鳞癌患者随机分为常规分割组 (常规组 )和后程加速超分割组 (后超组 )各 76例。用 15MV -X线照射 ,常规组 2Gy/次 ,总剂量 6 5～ 70Gy;后超组前 4周照射同常规组 ,第 5周起改为 1 2 5～ 1 5Gy/次 ,2次 /d ,总量 6 8～ 70Gy。结果 :常规组和后超组1、3、5年局部控制率分别为 6 9 7%、2 8 98%、10 88%和 78 92 %、6 6 14%、40 7% ;生存率分别为 76 2 7%、2 9 35 %、8 41%和78 91%、6 3 96 %、30 98% ,后超组明显高于常规组 (P <0 0 1)。结论 :后程加速超分割放疗明显提高了食管癌的疗效。
Objective: To study the effect of late-course accelerated hyperfraction radiotherapy on esophageal cancer. Methods: From April 1996 to April 1999, 152 patients with primary esophageal squamous cell carcinoma who were admitted to our hospital were randomly divided into routine segmental group (conventional group) and late accelerated group (76 cases) . With 15MV-X line irradiation, the conventional group 2Gy / times, a total dose of 65 ~ 70Gy; the last 4 weeks after the super-group irradiation with the conventional group, the first 5 weeks changed to 125 ~ 15Gy / times, 2 times / d , The total amount of 68 ~ 70Gy. Results: The local control rates at 1, 3 and 5 years were 69.7%, 28.8%, 10.88% and 78.92%, 66.14% and 40.7% respectively in the conventional group and the post-super-group; the survival rates were 76 2 7%, 2 9 35%, 8 41% and 78 91%, 6 3 96% and 30 98% respectively. The post-super-group was significantly higher than that of the conventional group (P 0 01). Conclusions: Late-course accelerated hyperfractionation radiotherapy significantly improves the efficacy of esophageal cancer.