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为探讨内皮素含量变化是否为缺血神经元损伤的危险因素及Ca~(2+)拮抗剂氟桂嗪对脑缺血的保护作用,采用放射免疫分析法,我们测定兔大脑中动脉阻断48小时后缺血区脑组织内皮素含量变化及氟桂嗪对其变化的影响。结果显示,缺血48小时后梗塞区脑组织内皮素含量明显升高(P<0.01),为对照组的10倍,而氟桂嗪能明显降低缺血区脑组织水、内皮素含量(P<0.05)。上述结果提示:缺血脑组织内皮素含量升高是导致缺血神经元损伤的重要因素,氟桂嗪对脑缺血有保护作用。
To investigate whether changes in endothelin levels are risk factors for ischemic neuronal injury and the protective effect of flunarizine, a Ca2 + antagonist, on cerebral ischemia, radioimmunoassay was used to measure the middle cerebral artery occlusion Changes of Endothelin in Brain Tissue of Ischemic Area after 48 Hours and Effects of Flunarizine on Its Changes. The results showed that the content of endothelin in cerebral infarction area was significantly increased (P <0.01) 48 hours after ischemia, which was 10 times of that in control group, while flunarizine significantly reduced the content of water and endothelin (P <0.05). The above results suggest that: Elevated endothelin levels in ischemic brain tissue is an important factor leading to ischemic neuronal damage, flunarizine has a protective effect on cerebral ischemia.