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Synthesis of isoxazolyl-1H-2,3-pyrrole dicarboxylate(4) was simply achieved by one-pot three component reaction of isoxazole amine(1) with diethyl acetylenedicarboxylate(DEAD)(2),and glyoxal (3),in acetonitrile catalyzed by diazabicyclo octane(DABCO).
Synthesis of isoxazolyl-1H-2,3-pyrrole dicarboxylate (4) was simply achieved by one-pot three component reaction of isoxazole amine with diethyl acetylenedicarboxylate (DEAD) (2), and glyoxal by diazabicyclo octane (DABCO).