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目的 观察高压氧 (HBO)、机械通气对海水淹溺肺水肿 (PE- SWD)兔肺组织学及呼吸功能的影响。方法 将 2 4只实验动物随机分为 PE- SWD组、HBO治疗组、机械通气治疗组。在不同时间点观察动脉血气分析、呼吸频率、呼吸动力学指标 ,实验结束后进行肺组织病理学检查。结果 HBO治疗组、机械通气治疗组各相同时间点 Pa O2 明显高于 PE- SWD组 (P<0 .0 1) ;HBO治疗组除个别时间点外 ,p H、Pa CO2 在整个治疗过程中变化不明显 ;机械通气治疗后 p H的变化规律略与 PE- SWD组相同 ,但治疗结束时仍低于其他组 (P<0 .0 1) ,Pa CO2 始终维持在一个较高的水平 (P<0 .0 1)。两种治疗都减轻了肺损伤程度 ,在降低气道峰压、提高肺顺应性方面两治疗组之间比较 ,差异无显著性意义 (P>0 .0 5 )。结论 HBO和机械通气治疗可明显纠正 PE- SWD时的低氧血症 ,减轻肺损伤程度 ,改善呼吸功能。
Objective To observe the effects of hyperbaric oxygen (HBO) and mechanical ventilation on the lung histology and respiratory function in seawater drowning pulmonary edema (PE-SWD) rabbits. Methods Twenty-four experimental animals were randomly divided into PE-SWD group, HBO-treated group and mechanical ventilation group. Arterial blood gas analysis, respiratory rate and respiratory dynamics were observed at different time points. Lung histopathology was performed after the experiment. Results In the HBO group and the mechanical ventilation group, the PaO 2 at the same time point was significantly higher than that in the PE-SWD group (P <0.01). In addition to the individual time points, The change of p H after mechanical ventilation was similar to that of PE-SWD group, but it was still lower than the other groups (P <0.01) at the end of treatment, Pa CO2 remained at a higher level P <0 .0 1). Both treatments relieved the degree of lung injury. There was no significant difference between the two treatment groups in reducing peak airway pressure and improving lung compliance (P> 0.05). Conclusion HBO and mechanical ventilation can obviously correct the hypoxemia during PE-SWD, reduce the degree of lung injury and improve the respiratory function.