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目的观察氟康唑预防性治疗急性再生障碍性贫血患者合并侵袭性真菌病(invasive fungal disease,IFD)的临床疗效及安全性。方法选择急性再生障碍性贫血合并存在IFD高危临床因素的病例作为观察对象,回顾性总结氟康唑针剂(大扶康)在预防性临床使用中的临床疗效、安全性分析、严重不良事件发生率;确立未预防治疗及预防治疗病例组,通过2组间的感染发生率、药物不良反应、治疗转归(包括粒细胞减少恢复的时间及调节性T细胞水平的纠正)、疾病预后等进行两两对照。结果及结论使用氟康唑作为预防性抗真菌治疗的策略对于减少深部真菌感染的发生、减少患者住院周期及费用、改善患者疾病预后等有着显著意义;在用药期间,未发现氟康唑针剂相关的不良反应,具有良好的安全性。可以作为预防性用药的优先推荐药物。
Objective To observe the clinical efficacy and safety of fluconazole in the prophylactic treatment of patients with acute aplastic anemia complicated with invasive fungal disease (IFD). Methods Acute aplastic anemia complicated with IFD high risk clinical factors was selected as the object of observation. The clinical efficacy, safety analysis and incidence of serious adverse events of fluconazole injection in preventive clinical use were retrospectively reviewed ; Established non-prevention treatment and prevention and treatment of cases, the incidence of infection between the two groups, adverse drug reactions, treatment outcome (including recovery of neutropenia and regulatory T-cell levels), disease prognosis Two contrasts. Results and Conclusion The use of fluconazole as a prophylactic antifungal therapy has significant effects on reducing the incidence of deep fungal infections, reducing the hospitalization period and cost, and improving the prognosis of patients. No fluconazole injection was found during the medication Adverse reactions, with good safety. Can be used as a preventive drug priority recommended drugs.