Penile urethral strictures have been managed by a staged surgical approach.In selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft (BMG) and tubularized during the same procedure,performing a “two-in-one” stage approach.We aim to identify stricture factors which indicate suitability for this two-in-one stage approach.We assess surgical outcome and compare with staged reconstruction.We conducted an observational descriptive study.The data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and 2017.The minimum follow-up was 6 months.Outcomes were assessed clinically,radiologically,and by flow-rate analysis.Failure was defined as recurrent stricture or any subsequent surgical or endoscopic intervention.Descriptive analysis of stricture characteristics and statistical comparison was made between groups.Of 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 staged.The mean stricture length was 2.8 cm (single stage) and 4.5 cm (staged).Etiology was lichen sclerosus (LS) 52.5％ (single stage) and 73.8％ hypospadias related (staged).40.7％ of patients had previous failed urethroplasties in the single-stage group and 81.2％ in the staged.The most common stricture locations were navicular fossa (39.0％) and distal penile urethra (59.3％) in the single-stage group and mid or proximal penile urethra (58.7％) in the staged group.Success rates were 89.8％ (single stage) and 81.3％ (staged).A trend toward a single-stage approach for select penile urethral strictures was noted.We conclude that a single-stage substitution penile urethroplasty using BMG as a “two-in-one” approach is associated with excellent functional outcomes.The most suitable strictures for this approach are distal,primary,and LS-related strictures.