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目的探讨狂犬疫苗免疫应答影响因素,为制定接种狂犬疫苗注意事项提供依据。方法在许昌市狂犬疫苗接种门诊对507例疫苗接种者行抗体测定,以问卷方式调查接种期间饮酒和使用免疫抑制剂情况,并按年龄、性别、饮酒、使用免疫抑制剂四种因素分组讨论其接种后的免疫效果。结果除性别因素外,年龄、饮酒与使用免疫抑制剂都对疫苗免疫应答有影响。结论在接种狂犬疫苗期间,应避免饮酒和使用免疫抑制剂。
Objective To investigate the influencing factors of rabies vaccine immune response and provide the basis for the formulation of precautions for vaccinating rabies vaccine. Methods In 507 rabies vaccine immunization clinics in Xuchang City, 507 vaccination patients were tested for antibody levels by questionnaire survey of alcohol use and immunosuppressive agents during vaccination, and by age, sex, alcohol consumption, the use of immunosuppressive agents in four groups were discussed in groups Immunization after vaccination. Results In addition to gender factors, age, alcohol consumption and the use of immunosuppressive agents have an impact on vaccine immune response. Conclusions During rabies vaccination, avoid drinking and using immunosuppressants.