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目的测定慢性肾功能衰竭患者血浆胱抑素C(CyctalinC)的水平并探讨其临床意义。方法用免疫比浊法测定l5例肾病综合征,20例慢性肾功能衰竭患者的血浆胱抑素C,其中6例慢性肾功能衰竭患者经肾移植好转后再次测定,另外测定了15例血浆肌酐(Cr)含量正常的急性肾小球肾炎患者血浆胱抑素C含量。并以20例体检正常者作对照。结果肾病综合征和慢性肾衰竭患者的血浆胱抑素C含量显著高于正常对照组(P<0.01),5例慢性肾衰患者肾移植好转后胱抑素C明显下降(P<0.01),但仍高于正常对照组。急性肾炎组与正常对照组比较差异无统计学意义(P>0.05)。结论胱抑素C有助于肾小球滤过功能的评估,血浆胱抑素C是肾脏病患者肾小球损害程度判断和疗效观察有价值的检测指标。
Objective To determine the level of plasma Cystin C in patients with chronic renal failure and to investigate its clinical significance. Methods Immunocytometry was used to determine the serum levels of cystatin C in 15 patients with nephrotic syndrome and 20 patients with chronic renal failure. Six patients with chronic renal failure were reperformed after renal transplantation. In addition, 15 patients with plasma creatinine (Cr) content of normal patients with acute glomerulonephritis plasma cystatin C content. And 20 cases of physical examination as a control. Results The content of cystatin C in patients with nephrotic syndrome and chronic renal failure was significantly higher than that in the normal control group (P <0.01). The cystatin C in 5 patients with chronic renal failure improved significantly after renal transplantation (P <0.01) But still higher than the normal control group. There was no significant difference between acute nephritis group and normal control group (P> 0.05). Conclusions Cystatin C is useful for the evaluation of glomerular filtration function. Plasma cystatin C is a valuable index for judging the degree of glomerular damage in nephrotic patients and observing the curative effect.