糖尿病肾病(diabetic nephropathy,DN)是糖尿病全身微血管合并症之一,最终可发展成终末期肾病,也是糖尿病最主要的死亡原因之一[1-2]。糖尿病肾病在临床上分为5期,一旦发病,缺乏有效的方法控制其发展,大多数患者转为慢性肾功能衰竭,威胁着患者的生命。因此,对DN各期影响因素的研究,可控制DN的进一步发生和进展,以往研究主要集中于糖代谢和血流动力学研究等[3-7]。本研究通过对 Diabetic nephropathy (DN), one of the common microvascular complications of diabetes, can eventually develop into end-stage renal disease and is one of the leading causes of death of diabetes [1-2]. Diabetic nephropathy is clinically divided into five stages. Once the disease develops, there is no effective way to control its development. Most of the patients turn to chronic renal failure, which threatens the life of the patient. Therefore, the various stages of the influence of DN study, can control the further occurrence of DN and progress, previous studies mainly focused on glucose metabolism and hemodynamic studies [3-7]. This study is correct