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目的:从病因学角度研究寒冷习服动物状态的阳虚特征。方法:每日冰水游泳模拟寒冷刺激,测量刺激后10-120min肛温变化数据;干预15d后检测内分泌、物质能量代谢、免疫等系统指标。并与糖皮质激素、寒性中药复方诱导的阳虚模型进行比较。结果:与正常组比较,冷刺激组环腺苷酸/环鸟甘酸比值显著降低(P<0.05),冷刺激后体温恢复速率升高,促甲状腺激素水平显著升高(P<0.05),睾酮和皮质类固醇水平有升高趋势,血糖、血清胆固醇水平有降低趋势,而免疫系统和肝肾功能指标无明显变化。结论:寒冷习服大鼠表现出以机体适应性改变的迟缓和低下为特征的阳虚状态,部分指标表现为适应性反馈的增强。本法诱导的阳虚状态与其他阳虚动物模型不完全相同,但在第二信使、总蛋白等指标方面具有类似变化。
Objective: To study the yang deficiency characteristics of cold acclimation animals from the perspective of etiology. Methods: The daily ice-water swimming simulates the cold stimulation, and measures the data of rectal temperature after 10-120min stimulation. The indexes of endocrine, material energy metabolism and immune are detected after intervention 15d. And with glucocorticoid, cold syndrome induced by Yang compound model were compared. Results: Compared with the normal group, the ratio of cyclic adenylate / cyclic guanosine in the cold stimulation group was significantly lower (P <0.05), the recovery rate of body temperature increased, the level of thyroid stimulating hormone increased significantly (P <0.05) And corticosteroid levels have increased, blood glucose, serum cholesterol levels have decreased, while the immune system and liver and kidney function indicators did not change significantly. CONCLUSION: Cold-acclimatized rats exhibit yang deficiency characterized by slow and low adaptive changes in the body. Some indicators show an increase in adaptive feedback. The yang deficiency induced by this method is not exactly the same as other animal models of yang deficiency, but has similar changes in indicators such as second messenger and total protein.