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目的 :探究无环鸟苷对脑脊液 (CSF)中单纯疱疹病毒 (HSV 1)DNA的影响。方法 :应用定量聚合酶链反应 (PCR)技术检测了 8例单纯疱疹病毒性脑炎 (HSE)患者系列CSF中HSV 1,并将无环鸟苷治疗前后的HSV 1DNA量作比较分析。结果 :无环鸟苷治疗后的CSF中 ,HSV 1DNA量较治疗前减低。结论 :无环鸟苷可使CSF中HSV 1DNA量减低 ,CSF中HSV 1DNA定量检测可作为判断无环鸟苷疗效及给药与否的依据之一。
Objective: To investigate the effect of acyclovir on herpes simplex virus (HSV 1) DNA in cerebrospinal fluid (CSF). Methods: Quantitative polymerase chain reaction (PCR) was used to detect HSV 1 in a series of CSF of 8 patients with herpes simplex encephalitis (HSE). The amount of HSV 1 DNA before and after acyclovir treatment was compared and analyzed. Results: The amount of HSV 1 DNA in CSF after acyclovir treatment was lower than that before treatment. CONCLUSION: Acyclovir reduces the amount of HSV 1 DNA in CSF and quantitative detection of HSV 1 DNA in CSF can be used as a basis for judging the efficacy and administration of acyclovir.