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目的:临床观察甲氨蝶呤联合米非司酮或中药治疗输卵管妊娠的疗效。方法:A组甲氨蝶呤1mg/kg单次肌内注射;B组甲氨蝶呤0.5～1.0mg/kg隔日肌内或静脉注射,共5次,联合四氢叶酸0.1mg/kg减毒,同时口服米非司酮50mg12h1次,共3天;C组甲氨蝶呤1mg/kg单次肌内注射联合传统中药,定期监测血β-HCG水平及盆腔包块和积液情况。结果:治愈率,A组77.2%,B组84.2%,C组83.3%,B、C两组治愈率高于A组,但没有统计学意义(P>0.05)。血β-HCG转阴时间、平均住院日,B、C两组较A组缩短,差异有非常显著(P<0.01)。B、C两组间差异无显著性(P>0.05)。结论:甲氨蝶呤联合中药治疗输卵管妊娠疗效好,副反应少,值得推广。
Objective: To observe the efficacy of methotrexate combined with mifepristone or traditional Chinese medicine in the treatment of tubal pregnancy. Methods: A group methotrexate 1mg / kg a single intramuscular injection; methotrexate group B methotrexate 0.5 ~ 1.0mg / kg every other day intramuscular or intravenous injection, a total of 5 times, combined with tetrahydrofolate 0.1mg / kg attenuated , While oral mifepristone 50mg12h1 times, a total of 3 days; C group methotrexate 1mg / kg a single intramuscular injection of traditional Chinese medicine, regular monitoring of serum β-HCG levels and pelvic mass and effusion. Results: The cure rate was 77.2% in group A, 84.2% in group B and 83.3% in group C, and the cure rates in group B and group C were higher than those in group A, but there was no statistical significance (P> 0.05). Blood β-HCG negative time, the average length of stay, B, C two groups shorter than the A group, the difference was significant (P <0.01). There was no significant difference between B and C (P> 0.05). Conclusion: Methotrexate combined with traditional Chinese medicine treatment of tubal pregnancy has good curative effect with few side effects and is worth promoting.