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目的:探讨血清肿瘤标记物在消化道恶性肿瘤诊断中的应用价值。方法:选取于我院诊治的消化道恶性肿瘤患者54例为观察组,同期诊治的消化道良性病变患者54例(对照组)和健康者54例(健康组),观察3组患者血清肿瘤标记物水平并进行对比分析。结果:观察组患者甲胎蛋白(AFP)、癌胚抗原(CEA)、糖原199(CA199)、癌抗原125(CA125)血清水平均明显高于对照组和健康组患者相应指标,组间差异在统计学上有意义(P<0.05);而对照组与健康组患者各指标差异不明显,在统计学上无意义(P>0.05);胃癌、胆囊胆管癌患者CEA、CA199、CA125明显升高,肝癌患者AFP、CA125明显升高,胰腺癌患者CA199明显升高,结直肠癌CEA、CA199明显升高;AFP、CEA、CA199、CA125联合检测阳性率明显高于单指标阳性率(P<0.05)。结论:AFP、CEA、CA199、CA125及联合检测对诊断消化道恶性肿瘤具有重要意义,值得推广。
Objective: To investigate the value of serum tumor markers in the diagnosis of gastrointestinal malignancies. Methods: Totally 54 patients with gastrointestinal malignancies diagnosed and treated in our hospital were selected as the observation group, 54 patients with benign digestive tract diseases (control group) and 54 healthy persons (healthy group) were treated during the same period. Serum tumor markers Material level and comparative analysis. Results: The serum levels of AFP, CEA, CA199 and CA125 in the observation group were significantly higher than those in the control group and the healthy group, and there was no significant difference between the two groups (P <0.05), while there was no significant difference between the control group and the healthy group (P> 0.05). The levels of CEA, CA199 and CA125 in gastric cancer and gallbladder cholangiocarcinoma were significantly increased The levels of AFP and CA125 in patients with HCC and hepatocellular carcinoma were significantly higher than those in patients with chronic pancreatitis. CA199 in patients with pancreatic cancer was significantly higher than that in patients with chronic pancreatitis. The positive rates of CEA and CA199 in colorectal cancer were significantly higher than those in patients with HCC. The positive rates of AFP, CEA, CA199 and CA125 were significantly higher than those of single- 0.05). Conclusion: AFP, CEA, CA199, CA125 and joint detection of gastrointestinal cancer diagnosis of great significance, it is worth promoting.