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奥曲肽是一种长效的生长抑素类似物,能增加狗和健康人胃肠移行性运动复合波(MMC)活动前相(AF_S)的频率,能明显改善硬皮病病人的假性肠梗阻症状,但其长期疗效尚不明确。红霉素是一种促动力剂,可刺激胃排空。本研究旨在确定奥曲肽和红霉素对特发性或硬皮病相关性假性肠梗阻的症状是否有持久的缓解作用,并通过胃肠测压,确定其药理作用,可预测病人对治疗会有持久临床效果的因素。 材料和方法:慢性肠梗阻病人14例,其中9例为特发性,5例为硬皮病性。测定基础状态和给予奥曲肽(50μg皮下注射)、红霉素
Octreotide is a long-acting somatostatin analogue, which can increase the frequency of AF_S in the gastrointestinal motility complex (MMC) of dogs and healthy people, and can significantly improve the false intestinal obstruction in patients with scleroderma Symptoms, but its long-term efficacy is not clear. Erythromycin is a prokinetic agent that stimulates gastric emptying. The purpose of this study was to determine whether octreotide and erythromycin have a sustained ameliorating effect on symptoms of idiopathic or scleroderma-associated pseudo-intestinal obstruction and to determine their pharmacological effects by gastrointestinal manometry to predict patient response to treatment There will be a long-term clinical effect of the factors. Materials and Methods: 14 patients with chronic intestinal obstruction, of which 9 cases of idiopathic, 5 cases of scleroderma. Baseline status and administration of octreotide (50 μg subcutaneously), erythromycin