The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD. The c-Jun NH2-terminal Kinase (JNK) pathway represents a sub-group of the mitogen-activated protein (MAP) kinases which plays an important role in various inflamatory diseases states, including inflammatory bowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockade of the JNK pathway with JNK inhibitors in animal models of IBD lead to resolution of intestinal inflammation. Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD.