华法林是心脏瓣膜置换术后标准抗凝治疗药物。然而,华法林抗凝疗效影响因素复杂,患者自身遗传因素,疾病状态,尤其是药物相互作用,都对华法林抗凝疗效产生影响。本文分析2例药物相互作用导致华法林抗凝作用增强的原由,为临床合理使用华法林提供用药参考。1案例介绍1.1案例1患者,女,60岁,因反复胸闷、心悸十余年,加重3天入院。患者既往有风湿性心脏瓣膜病和阵发性心房颤动病史,服用呋塞米、螺内酯、卡维地洛和华 Warfarin is a standard anticoagulant medication after heart valve replacement. However, warfarin anticoagulant efficacy of complex factors, the patient’s own genetic factors, disease status, especially drug interactions, have an effect on warfarin anticoagulant effect. This article analyzes two cases of drug interactions lead to warfarin anticoagulant effect of the reasons for the rational use of warfarin clinically provide medication reference. 1 case introduction 1.1 case 1 patient, female, 60 years old, due to repeated chest tightness, palpitations more than ten years, increased 3 days admission. Patients with previous rheumatic heart disease and paroxysmal atrial fibrillation history, taking furosemide, spironolactone, carvedilol and China