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目的:探讨survivin、NF-κB在肾癌中的表达,及其与临床病理指标的关系。方法:采用免疫组织化学技术检测40例肾癌组织及10例正常肾组织中survivin、NF-κB的表达情况。结果:survivin在肾癌组织阳性表达率为72.5%,在对照组中不表达,两者比较差异有统计学意义(P<0.05);TNM分期Ⅲ、Ⅳ期肾癌组织中survivin阳性表达率高于Ⅰ、Ⅱ期(P<0.05)。NF-κB在肾癌组织阳性表达率为65.0%(26/40),在对照组中阳性表达率为20.0%(2/10),两者比较差异有统计学意义(P<0.05)。NF-κB的表达在中低分化肾癌组织中阳性表达率高于高分化肾癌组织(P<0.05);在Ⅲ、Ⅳ期肿瘤组织中表达高于Ⅰ、Ⅱ期(P<0.05)。NF-κB的表达与survivin的表达呈正相关(r=0.590,P<0.05)。结论:survivin、NF-κB在肾癌的发生、发展中起着不同程度的作用;联合检测survivin、NF-κB有助于对肾癌恶性程度的判定及侵袭转移能力的评估,进而为肾癌的预后分析及临床治疗提供依据。
Objective: To investigate the expression of survivin and NF-κB in renal cell carcinoma and its relationship with clinicopathological parameters. Methods: The expressions of survivin and NF-κB in 40 cases of renal cell carcinoma and 10 cases of normal renal tissues were detected by immunohistochemistry. Results: The positive expression rate of survivin in renal cell carcinoma was 72.5%, but not in the control group (P <0.05). The positive rates of survivin in TNM stage Ⅲ and Ⅳ were high In Ⅰ, Ⅱ period (P <0.05). The positive expression rate of NF-κB in renal cell carcinoma was 65.0% (26/40) and in the control group was 20.0% (2/10), the difference was statistically significant (P <0.05). The positive expression rate of NF-κB in moderate and poorly differentiated renal cell carcinoma tissues was higher than that in well-differentiated renal cell carcinoma tissues (P <0.05). The expression of NF-κB in stage Ⅲ and Ⅳ tumors was higher than that in stage Ⅰ and Ⅱ (P <0.05). There was a positive correlation between NF-κB expression and survivin expression (r = 0.590, P <0.05). Conclusions: Survivin and NF-κB play different roles in the development and progression of renal cell carcinoma. Combined detection of survivin and NF-κB is helpful to evaluate the malignant degree and invasion and metastasis of renal cell carcinoma, Prognosis analysis and clinical treatment to provide the basis.