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目的 采用免疫组化方法检测了 41例胃黏膜球样异型增生Ki -67、P5 3、bcl -2及bax的表达 ,以探讨其增殖活性程度和与癌的关系。方法 复查胜利石油管理局中心医院 1993年～ 1994年收检的外科手术切除胃癌标本 ,从中检出伴有球样异型增生者 41例 ,包括球样异型增生I级 2 3例 ,II级 11例 ,III级 7例。免疫组化标记Ki -67、P5 3、bcl-2及bax。结果 41例胃黏膜球样异型增生分别见于高分化腺癌、低分化腺癌、黏液腺癌、印戒细胞癌。 2例见与印戒细胞癌有形态移行 ,3例见与低分化管状腺癌移行。多数球样异型增生细胞显示Ki-67、P5 3、bcl -2及bax阳性。与正常胃黏膜比较 ,球样异型增生细胞Ki -67、P5 3表达增高 ,高级别者与癌接近。球样异型增生细胞bcl-2表达较低 ,bax表达较高 ,但较高级别的球样异型增生细胞bcl -2表达增高 ,bcl-2 /bax比值增高。结论 胃黏膜球样异型增生细胞增生活跃 ,可能与多种类型胃癌的发生有关。
Objective To detect the expression of Ki-67, P53, bcl-2 and bax in 41 cases of gastric mucosal dysplasia by immunohistochemistry to investigate their relationship with the degree of proliferative activity and cancer. Methods A total of 41 patients with ball-shaped dysplasia, including 23 cases of ball-like dysplasia, 23 cases of grade II and 11 cases of grade II, were examined with surgical resection of gastric cancer collected from 1993 to 1994 in Shengli Petroleum Administration Central Hospital. , Grade III in 7 cases. Immunohistochemical markers Ki-67, P5 3, bcl-2 and bax. Results 41 cases of gastric mucosal dysplasia were found in well-differentiated adenocarcinoma, poorly differentiated adenocarcinoma, mucinous adenocarcinoma, signet-ring cell carcinoma. 2 cases see signet ring cell carcinoma with morphology transition, 3 cases with poorly differentiated tubular adenocarcinoma migration. Most globular-like dysplasia cells show Ki-67, P53, bcl-2, and bax-positive. Compared with normal gastric mucosa, the expression of Ki-67 and P53 in globular dysplasia cells increased, and those in higher grade and carcinoma were close. The globular-like dysplasia had lower expression of bcl-2 and higher expression of bax, but the expression of bcl-2 increased and the ratio of bcl-2 / bax increased in higher-grade globular dysplasia. Conclusions Gastrodial bulb-like dysplasia is hyperplasia, which may be related to the occurrence of various types of gastric cancer.