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[目的]观察利胆化瘀片的镇痛抗炎作用。[方法]以阿司匹林为对照药物,观察利胆化瘀片对小鼠热刺激和化学刺激所致疼痛的影响;采用二甲苯、冰醋酸等致炎剂,观察利胆化瘀片对小鼠耳廓肿胀及血管通透性的影响。[结果]利胆化瘀片可明显提高热板致痛的痛阈,维持时间长达4 h以上,且随剂量增加而痛阈值增大;减少小鼠因冰醋酸所致的扭体次数,且随剂量增加而次数减少;明显抑制二甲苯所致的耳廓肿胀;对抗冰醋酸所致的腹腔毛细血管通透性增加。[结论]利胆化瘀片具有明显的镇痛抗炎作用。
[Objective] To observe the analgesic and anti-inflammatory effects of Lidan Huayu Tablet. [Methods] Aspirin was used as a control drug to observe the effect of Lidan Huayu Tablet on pain caused by thermal stimulation and chemical stimulation in mice. Xanthine and acetic acid were used as inflammatory agents to observe the effect of Lidan Huayu Tablet on mouse ear Profile swelling and vascular permeability effects. [Results] Lidan Huayu Tablets could significantly increase the pain threshold of hot plate, and lasted for more than 4 hours. The pain threshold was increased with the increase of dose, and the number of writhing caused by glacial acetic acid in mice was decreased. And with the increase in the number of doses decreased; significantly inhibited xylene caused ear swelling; anti-glacial acetic acid caused by increased capillary permeability of the abdominal cavity. [Conclusion] Lidan Huayu Tablet has obvious analgesic and anti-inflammatory effects.