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用外周给药法观察了利多卡因（ｌｉｄｏｃａｉｎｅ）对四种惊厥发作的影响。利多卡因静脉注射（ｉｖ）０．４，０．８，１．６ｍｇ·ｋｇ￣（－１）可显著地和剂量相关地减弱或消除大鼠听源性惊厥（ａｕｄｉｏｇｅｎｉｃｓｒｅｉｓｕｒｅ，ＡＳ）。腹腔注射（ｉｐ）利多卡因也有同样效应。在ＡＳ反应阴性大鼠上，利多卡因（１．６ｍｇ·ｋｇ￣（－１））可对抗士的宁（ｓｔｒｙｃｈｎｉｎｃ）所诱发的ＡＳ，但对大鼠士的宁惊厥却略有易化作用。利多卡因在（ｉｐ）０．８ｍｇ·ｋｇ（－１）时可延缓小鼠异烟肼（ｉｓｏｎｉａｚｉｄｃ）发作潜伏期和死亡期，但在ｉｐ，０．４，１．０ｍｇ·ｋｇ（－１）时不能对抗小鼠士的宁惊厥。本文对利多卡因抗惊厥作用的膜稳定机制进行了讨论。
The effects of lidocaine on four seizures were observed by peripheral administration. Intravenous injection of lidocaine (iv) at 0.4, 0.8, and 1.6 mg · kg -1 significantly attenuated or eliminated audiogenicsrelation (AS) in rats in a dose-dependent manner. Intraperitoneal injection of ip lidocaine has the same effect. In AS-responsive rats, lidocaine (1.6 mg · kg -1) was able to counteract the strychnine-induced AS but had a slightly facilitated effect on the anticonvulsant in rats . Lidocaine could delay the onset and death of isoniazidc in mice at (ip) 0.8 mg · kg -1, but at ip, 0.4 and 1.0 mg · kg -1, When the mice can not fight Ning convulsions. This article discusses the anticonvulsant membrane-stabilizing mechanism of lidocaine.