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环氧化酶(COX)是花生四烯酸合成前列腺素(PG)过程中一个重要的限速酶。普遍认为COX-1为生理酶,由它产生的PG参与机体正常生理过程和保护功能,如保护胃肠黏膜完整性、调节血小板功能和脏器血流。而COX-2在生理情况下几乎不表达,在许多促炎症和致突变因素的刺激下,COX-2可被诱导
Cyclooxygenase (COX) is an important rate-limiting enzyme in the synthesis of prostaglandins (PGs) by arachidonic acid. It is generally accepted that COX-1 is a physiological enzyme and PG produced by it is involved in the normal physiological processes and protective functions of the body, such as the protection of gastrointestinal mucosal integrity, regulation of platelet function and organ blood flow. However, COX-2 is rarely expressed under physiological conditions. COX-2 can be induced by many proinflammatory and mutagenic factors