将盐酸依匹斯汀、预胶化淀粉和微晶纤维素混匀后装填胶囊。考察了原料辅料相容性、胶囊内容物的粉体学性质和溶出度等。初步稳定性考察结果表明,所得盐酸依匹斯汀胶囊在(40±2)℃、相对湿度(75±5)%条件下放置6个月或常温放置12个月,含量和溶出度无明显改变,有关物质略有增加。 Capsules were filled with epinastine hydrochloride, pregelatinized starch and microcrystalline cellulose. The compatibility of raw materials and excipients, powder properties and dissolution of the capsule contents were investigated. The results of the preliminary stability study showed that the content and dissolution of the obtained epinastine hydrochloride capsule were not significantly changed after being placed for 6 months under the conditions of (40 ± 2) ℃, relative humidity (75 ± 5)% or 12 months at room temperature , The related substances increased slightly.