非侵入性产前诊断一直是遗传工作者和产科工作者的目标,分离孕妇外周血中的胎儿细胞作产前诊断使这一设想成为现实。但目前这一技术费时长、操作复杂,富集的胎儿细胞数量少、纯度不高,很难广泛应用于临床。近年来开展的从孕妇外周血中直接提取胎儿DNA作产前诊断受到人们日益重? Non-invasive prenatal diagnosis has long been the goal of both geneticists and obstetricians, and the idea of ​​separating prenatal diagnosis of fetal cells in the peripheral blood of pregnant women makes this vision a reality. However, at present, this technique takes a long time and complicates the operation. The enrichment of fetal cells is small in number and purity is not high, so it is hard to be widely used in clinical practice. In recent years, the extraction of fetal DNA from pregnant women’s peripheral blood for prenatal diagnosis has been increasingly serious?