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血液与脑组织之间的物质交换是有选择性的。早在1885年Ehricn在研究网状内皮系统吞噬机能时就已发现,给动物皮下注射苯胺染料,体内许多组织可被着色,唯独神经组织却染不上。他将其他酸性染料注入动脉静脉,发现内脏器官均被着色,但中枢神经系统未被染色。Lewomdousky(1900)曾以小量亚铁氰化物注入兔的脑脊液内,却未引起明显的反应。1913年Goldman曾用活性染料作了类似的实验,发现这种染料静脉注射后,并不产生中毒症状,但除脑以外,身体其他部位均被染成蓝色。根据上述现象,Stern和Gauthier二人在1921年首次提
The exchange of matter between blood and brain tissue is selective. As early as 1885, Ehricn, when studying the phagocytic function of the reticuloendothelial system, discovered that injecting aniline dyes subcutaneously into animals can cause many tissues in the body to be colored, but only the nervous tissue can not stained. He injected other acid dyes into the arterial veins and found that the internal organs were colored but the central nervous system was not stained. Lewomdousky (1900) was infused into the cerebrospinal fluid of rabbits with a small amount of ferrocyanide, but did not elicit a significant response. In 1913, Goldman used a reactive dye to make a similar experiment and found that the dye did not produce poisoning symptoms after intravenous injection, but the rest of the body was dyed blue except for the brain. According to the above phenomenon, Stern and Gauthier first mentioned in 1921